Endoscopy of Brunner's Gland Adenoma Normal Brunner's glands are found in the highest concentration in the proximal duodenum and found normally extending to the proximal jejunum. These glands secrete a viscous alkaline fluid that is thought to protect the duodenalmucosa from the effects of gastric acid. This fluid also contains a glycoprotein that binds to the mucosa to further protect it. Brunner's glands also secrete enterogastrone, a hormone that inhibits gastric acid secretion. The precise etiology of Brunner's gland hyperplasia has not been completely elucidated. One theory is that the glands are stimulated to proliferate by increased acid production. However, no studies have confirmed this hypothesis. Brunner's gland adenomas are rare duodenal lesions that can present with hemorrhage or signs and symptoms of obstruction. They are not true adenomas, but are actually hamartomas with little to no malignant potential. These lesions should be treated with endoscopicpolypectomy if possible, but surgical resection is an acceptable option.
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