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Diffuse Adenocarcinoma with signet ring cells (4 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Macrocospic specimen Great size and deep ulcer is observed with irregular folds

Diffuse Adenocarcinoma with signet ring cells (5 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Another macroscopic aspect Linitis plastica refers to the diffuse proliferation of the connective tissue, resulting in tissue thickening so that the stomach is constricted and rigid. Pathological...

Diffuse Adenocarcinoma with signet ring cells (6 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Macroscopic view of the stomach at the surgery, the lesion is infiltrating the serosa.

Diffuse Adenocarcinoma with signet ring cells (7 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Macroscopic detail of the neoplasia

Diffuse Adenocarcinoma with signet ring cells (8 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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ALTHOUGH GASTRIC CARCINOMA occurs with reduced frequency, it is still a prevalent disease. Most gastric carcinomas are classified as adenocarcinomas due to glandular growth pattern and/or presumed...

Diffuse Adenocarcinoma with signet ring cells (9 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Irregular infiltration is observed, penetration of the tumor through the serosa.

Diffuse Adenocarcinoma with signet ring cells (10 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Gastric linitis plastica is a very particular malignant gastric tumor different from the usual gastric adenocarcinoma. Linitis plastica refers to the diffuse proliferation of the connective tissue,...

Diffuse Adenocarcinoma with signet ring cells (11 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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In this photography the diffuse thickening of the tumor around the ulcer with extension in the form of arm is observed.

Diffuse Adenocarcinoma with signet ring cells (12 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Diet appears to play a major role in the development of stomach cancer. Nitroso compounds such as nitrites (found in smoked meats and fish) and nitrates (used in food preservatives), and high salt intake,...

Diffuse Adenocarcinoma with signet ring cells (13 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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A bacteria called Helicobacter pylori represents an additional risk factor for gastric cancer, particularly those cancers occurring in the distal portion (antrum) of the stomach. This infection may...

Diffuse Adenocarcinoma with signet ring cells (14 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Gastric adenocarcinoma may spread via direct extension through the stomach wall into adjacent organs (spleen, pancreas, colon, esophagus, diaphragm) Alternatively, cancer cells may spread through lymphatic...

Diffuse Adenocarcinoma with signet ring cells (15 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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Endoscopic biopsy at high power showing the undifferentiated signet ring cells of the ulcer. Finally, gastric cancers are seen at increased frequency in certain familial cancer syndromes, such as...

Diffuse Adenocarcinoma with signet ring cells (17 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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This picture shows the border of the ulcerated neoplasia.

Diffuse Adenocarcinoma with signet ring cells (18 of 18)
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Diffuse Adenocarcinoma with signet ring cells...

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High power detail of malignant gastric tumor with signet ring cells.

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