rheumatoid arthritis

Rheumatoid arthritis

It is a chronic inflammatory connective tissue disease caused by an autoimmune reaction. The cause is unknown.


Symmetrical inflammation of multiple joints (leading to destruction of cartilage and bone epiphysis, changes in non-joint, systemic changes, atrophy of interosseous muscles and thenar muscle atrophy, attachment tendon and tendons sheaths, subluxation of distal palmar phalanges, changes "swan neck".


Uses two established standards of procedure. Older - ACR (American College of Rheumatology) 1987 implies the necessity to meet 4 of 7 following criteria:

• morning stiffness of joints lasting at least 1 hour, min. 6 weeks

• inflammation of three or more joints occurring at the same time,
established by a physician, lasting for at least 6 weeks

• arthritis hand (wrist, metacarpophalangeal or proximal interphalangeal ) lasting for at least 6 weeks

• symmetric arthritis lasting at least 6 weeks

• the presence of rheumatoid nodules

• the presence of rheumatoid factor

• radiological changes - erosions and osteoporosis.

Newer eligibility criteria (ACR classification criteria and the EULAR, 2010 r) are used for patients who suffer from overt synovitis of at least one joint (swelling) and the inability to explain another disease of arthritis (lupus erythematosus, psoriatic arthritis, gout ). It is estimated attachment joints, rheumatoid factor, laboratory markers of inflammation, duration of symptoms.

Types - depending on the severity of changes

A. Type of mild progression (5% -10% of patients), disease-modifying drugs inhibit the growth of the disease. Rheumatoid factor is present only in a few percent of the patients.

B. Type of slight progression (5-10% of patients). Rheumatoid factor is present in most patients. Symptomatic treatment brings relief, although there constant progression of the disease.
C. Type of high disease progression (60% -90% of patients). Rheumatoid factor is present in high concentration from the beginning of the disease. Rapid progress and destruction, despite treatment.

The treatment - are used disease-modifying drugs (to prevent destructive changes in the course of rheumatic diseases), such as: gold salts, azathioprine, cyclosporine, penicillamine, hydroxychloroquine, leflunomide, methotrexate, NSAIDs (e.g. diclofenac) and glucocorticoids; recently are used modern biological treatment (TNF inhibitors, drugs that reduce the activity of autoimmune T cells, interleukin-1 inhibitors, monoclonal antibodies against B cells, inhibitors of T cell stimulation, interleukin-6 blockers).

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The NHS Long Term Plan and rheumatoid arthritis:...

Specialty:  Rheumatology
views: 128 comments: 0

Whilst care for the over 400,000 people diagnosed with rheumatoid arthritis (RA) has improved over recent years, there are still high levels of unmet need and patients not receiving optimal treatment...

Editor's Picks Spotlight: Risk Factors for Rheumatoid...

Specialty:  Rheumatology
views: 323 comments: 0

Demographic, Lifestyle, and Serologic Risk Factors for Rheumatoid Arthritis (RA)–associated Bronchiectasis: Role of RA-related Autoantibodies Gregory McDermott, Ritu Gill, Staci Gagne, Suzanne Byrne,...

Can we predict response to Methotrexate in Rheumatoid...

Specialty:  Rheumatology
views: 349 comments: 0

Can we predict response to Methotrexate in Rheumatoid Arthritis? Results from a multicenter RCT

Arthritis Of The Fingers - Everything You Need...

views: 3039 comments: 0

Arthritis can affect any joint in the body but it is commonly seen in the joints of the fingers. The different types of arthritis and the pattern of joint involvement include osteoarthritis, psoriatic...

Leflunomide (DMARD) Pharmacology - Mechanism...

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Leflunomide is an immunosuppressant used to treat RA and psoriatic arthritis and Multiple sclerosis. Leflunomide is a prodrug that is rapidly and almost completely metabolized following oral administration...

Methotrexate - Pharmacology (DMARD, Mechanism...

views: 6269 comments: 0

Buy PDFs here: http://armandoh.org/shop "Methotrexate is a first line treatment for RA and other autoimmune diseases. It is an immunosuppressant meaning it suppresses the immune system. Methotrexate...

Banana In The Eye

Specialty:  Ophthalmology
views: 3405 comments: 0

This video shows a lamellar crescent shaped corneal patch graft for a perforated peripheral corneal ulcer in a patient with rheumatoid arthritis. Video by Surgeon: Avi Solomon, M.D.

Shoulder Arthroplasty

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Reverse Total Shoulder Arthroplasty presented by Dr. Alejandro Badia. Reverse total shoulder arthroplasty is currently being used to treat selected patients with disabling shoulder arthropathy. It can...

Elbow Capsule Incision In Rheumatoid Arthitis

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The video presents elbow capsule incision in the patient suffering from rheumatoid arthritis using arthroscopy method.

Rheumatoid arthritis - Joint - Histopathology

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Author presents histopathological image of rheumatoid arthritis.

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