Endoscopic View of Severe Ulcerative Colitis Inflammatory pseudopolyps may be seen in patients with severe ulcerative colitis, and occur due to inflamed and regenerating mucosa surrounded by ulcerations, resulting in a cobblestone appearance at endoscopy. Pseudopolyps do not regress with treatment and tend to persist even in the presence of quiescent disease. They cannot be distinguished from neoplastic polyps on the basis of endoscopic appearance alone, and therefore histopathologic examination of polyps that display atypical features may be necessary to exclude dysplasia and/or malignancy.
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