Mucosal biopsies are useful both for confirming the diagnosis and for accurately defining the extent of ulcerative colitis, which can be underestimated on the basis of endoscopic appearance alone. In addition to its role in the initial evaluation of IBD, endoscopy is an effective tool in the reevaluation of patients with indeterminate colitis. According to a prospective population-based study, 33% of patients with indeterminate colitis could be reclassified as ulcerative colitis after 1-2 years of follow-up
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