Tongue of Barretts mucosa showing cerebriform villous architecture. The salmon-colored mucosa in the distal esophagus is columnar and consists of a mosaic of fundic mucosa, cardiac mucosa, and intestinal metaplasia. The yield of intestinal metaplasia from biopsies of columnar-type mucosa in the distal esophagus varies from 25% to 50% in short-segment Barretts esophagus to 80% in longsegment Barretts esophagus. Ideally, a method that improves the visualization of the mucosal surface would aid in the detection of Barretts esophagus and assist in more accurate surveillance. Magnification endoscopy with chromoendoscopy provides a unique approach with a more specific evaluation of the fine details of the mucosal surface and high-yield targeted biopsies for a more accurate diagnosis.
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