Chromoendoscopy using Lugol's solution. Staining of the mucosa with Lugol's solution during endoscopy has been suggested to identify early cancer and dysplasia that may improve prognosis. It has been shown that 40-60% of patients with typical reflux symptoms have no esophageal mucosal injury Lugol chromoendoscopy may be useful for the diagnosis of so-called endoscopy-negative GERD.
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