EndoscopicImage of Gastrointestinal Stromal Tumour of the Rectum. Gastrointestinal stromal tumors (GIST) were described in 1983 as tumors in the gastrointestinal tract and mesentery, characterized by a specific histological and immunohistochemical pattern. These tumors occurs at a median age of 60 years in most series, with a slight male predominance. Subsequently, GIST have been shown to exhibit typical activating mutations of the KIT or PDGFRA protooncogenes, which are the likely causal molecular events of GIST. GIST have a high risk of metastatic relapse, specifically in the liver and peritoneum, after initial surgery for localized disease.
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