A 26 year-old man, who was under course of antibiotic therapy underwent a watery diarrhea and sepsis. Typical pseudomembranes adherent to the colonic mucosa in antibiotic-associated colitis. The illness occurs after a course of broad-spectrum antibiotics, which permitted an overgrowth of the bacteria Clostridium difficile. Discrete, rounded collections of adherent, white to yellow exudate can coalesce into large swatches. Lesions are most common in the rectum but can affect the entire colon and appendix.
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