Human studies have been performed with photodynamic therapy (PDT), argon plasma coagulation (APC), multipolar electrocoagulation (MPEC), heater probes, and various forms of lasers, endoscopic mucosal resection (EMR), cryotherapy, and radiofrequency ablation. Ablative therapy remains largely investigational with the exception of PDT, which is approved by the Food and Drug Administration (FDA) for high-grade dysplasia only.
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