Gross appearance of gallblader carcinoma filling all the cavity and invading the wall.
The exact etiology of GB carcinoma is unknown; however,
several associated factors have been identified. One
hypothesis suggests that irritation of the GB mucosa by
stones causes chronic inflammation and, followed by
repetitive epithelial repair, may cause malignant
transformation. Approximately 15 years is required for
dysplasia to progress to invasive carcinoma.
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