Close up image with zoom. The mucosa has a mosaic pattern. Endoscopic features of cryptosporidiosis of the colon. The involved mucosa may be reddened and may be covered with a mucoid exudate. The major histologic findings in the small intestine are parcial villus atrophy and crypt hyperplasia, associated with marked acute and chronic inflammation. The lesions are diffuse in the small intestine and cause a spruelike patterns on a barium x-ray enema. In the colon, crypt epithelial cell damage associated with cryptosporidiosis may be seen focally or diffusely. Cryptosporidium infections have been described to infect the epithelium in every portion of the gastrointestinal tract from the pharynx to the rectum.
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