Extensive ulcerative colitis (UC) with pseudopolyposis The severity of the inflammatory reaction seen correlates well with the clinical course of the disease. Most of the cardinal features of UC include: Inflammation limited to the mucosa and superficial submucosa although deeper layers can be involved in fulminant colitis. Diffuse and severe distortion of crypt architecture, although this can take 6/52 to develop. Diffuse and severe reduction in crypt density. Heavy infiltration of inflammatory cells in the lamina propria. In active disease neutrophils are prevalent and these can form crypt abscesses which are a reliable indicator of disease severity. Severe mucin depletion. Superficial ulceration in active disease.
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