Ulcerative Colitis. Moderate to severe colitis is characterized by granularity, friability, exudate, spontaneous bleeding and increasingly larger areas of ulceration. Pathophysiology: Ulcerative colitis is defined as continuous idiopathic inflammation of the colonic or rectal mucosa. The rectum is involved in more than 95% of cases. Some authorities believe that the rectum is always involved in an untreated patient. Partial healing may occur in a patient treated with topical therapy, creating diagnostic confusion
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