Toxic megacolon complicating pseudomembranous colitis Toxic megacolon is associated with an acute transmural fulminant colitis with the neurogenic loss of motor tone. The result is the rapid development of colonic dilatation due to damage to the entire wall of the colon associated with neuromuscular degeneration. Histologic examination reveals extensive sloughing of the mucosa and frequent necrosis of the muscle layers of the bowel wall. Thinning of the muscle layer of the colon often occurs.
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