Pathology Associated with Infection by Other Species of Schistosome. S. japonicum Infection The primary cause of pathology here is a granulomatous reaction to egg trapped in the liver, and both the acute and chronic aspects of the disease are similar to that of S. mansoni infections, although the acute disease Katayama fever, is more common here than for S. mansoni. The chronic stage of the disease may also be more severe, owing to the greater egg output and longevity of S. japonicum females compared with those of S. mansoni.
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