Brunner's gland adenoma (BGA) of the duodenum appear to be nodular hyperplasia of the normal Brunner's gland with an unusual admixture of normal tissues, including ducts, adipose tissue and lymphoid tissue. Overgrowth of Brunner's gland forming a tumour larger than 1cm in size in diameter is referred to as BGA and less than 1cm as Brunner's gland hyperplasia. The etiology of Brunner's gland adenoma remains obscure. Concurrent helicobacter pylori infection is very common in patients with Brunner's gland adenoma. However, the role of H. pylori infection in the pathogenesis and development of Brunner's gland hyperplasia remains unclear.
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