Upper endoscopy image showing Gastrointestinal Stromal tumor (GIST) Most GIST of stomach are asymptomatic but ulceration may cause pain and signs of gastrointestinal bleeding. Microscopically, GIST are formed of fasicles of benign-appearing spindle cells without nuclear atypia; mitoses are sparse or absent, and necrosis virtually never occurs. The nucleus is centrally located and oval but may be displaced to one side by distinct vacuoles suggesting signet-ring cells. These vacuoles do not contain fat or mucosubstances, which differentiates them from liposarcomas and carcinomas.
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