When Helicobacter eradication has been deemed to have failed, more conventional therapies can be used. While surgery has, in the past, been the mainstay of treatment for gastric lymphoma, this is no longer the case. Several studies have shown that, although the lymphoma is usually concentrated in one part of the stomach, there are small deposits all over the stomach lining. Both radiotherapy and chemotherapy have been shown to be highly effective in the treatment of gastric MALT lymphoma. Single-agent chemotherapy with alkylating agents (substances which are used to treat some cancers by interfering with cell metabolism and growth) such as cyclophosphamide or chlorambucil or nucleoside analogues (other drugs used to check the growth of lymphoma cells) such as cladribine appear to have equal activity.
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