Multiple studies have demonstrated that variceal ligation has a remarkably low complication rate. A number of studies have been completed to compare the efficacy and safety of endoscopicsclerotherapy versus endoscopic variceal ligation. These studies demonstrate that ligation is equally as effective as sclerotherapy in achieving control of acute variceal bleeding. rebleeding and mortality are less after variceal ligation. Also, the number of procedures required to achieve obliteration of varices is less with variceal ligation than with sclerotherapy in nearly all comparative studies. Finally, complications, both minor and major, appear to be less with variceal ligation than sclerotherapy.
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