Gastrointestinal Stromal tumors (GIST) are rare tumors, accounting for less than 3% of gastrointestinal neoplasms, however, they are the most frequent mesenchymal tumors of the GI tract. All GISTs are defined by the expression of CD117, a tyrosine kinase growth factor receptor, as opposed to other tumors like leiomyomas, leiomyosarcomas and neurogenic tumors. 70-80% are benign, and the majority is located in the stomach and small bowel, but also they can arise from any portion of the GI tract as well as from the mesentery, omentum and retroperitoneum. Malignant GISTs are usually large (>5 cm), with high mitotic index, and can metastasize to the liver and peritoneum.
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