Colonic tuberculosis as a diagnostic challenge Deep ulcerations exposing the deeper layers of the colonic wall and leaving islands of normal mucosa, with deformity of the lumen. In this case of tuberculosis of the colon resemble a Crohn's disease, lesions are typically discontinuous. They can be adjacent to normal tissue, resulting in "skip areas" as in Crohn's disease. In cases where the information available does not reveal a definite differentiation between colonic tuberculosis and Crohn’s disease, corticosteroids should be withheld. The administration of corticosteroids to a patient with colonic tuberculosis may have disastrous results, and a therapeutic trial of antituberculous drugs should be considered instead.
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