Endoscopic Image of Pseudomembranous Colitis Symptoms Pseudomembranous colitis is usually associated with watery diarrhea (99%), fever (29%), abdominal pain or cramping (33%) and leukocytosis (61%) [10]. In a study of 48 patients with endoscopic PMC, the above symptoms usually occurred after 4 days of antibiotic treatment , but symptoms can occur up to 6 weeks after antibiotics have been discontinued. Symptoms can occur within a day or two of starting antibiotics, suggesting that alteration in the colonic flora can develop rapidly. Cases have even been documented after a single dose of cephalosporin given as preoperative prophylaxis.
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