Endoscopic Appearance of Severe Ulcerative Colitis Localized giant pseudopolyposis is seen in both UC and Crohn’s disease. Pseudopolyps are formed by ulceration, which undermines the muscularis mucosae and creates mucosal tags that remain as polyps after regeneration. Localized giant pseudopolyposis is considered to result from enlarged mucosal tags that become elongated by the tractive force of peristalsis and the fecal stream.
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