Patients with ulcerative colitis are susceptible to superimposed bacterial or viral colitis, and furthermore, one third of patients with suspected IBD may in fact have an underlying infectious etiology for their colitis. Rectal biopsies showing histopathologic findings of a chronic inflammatory infiltrate, basal lymphoid aggregates, and architectural distortion may be useful in differentiating IBD from self-limited colitis with a probability of up to 80%
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