Ulcerative Colitis. Necrosis, edema, exudate and friability are observed. Causes: An unknown factor causes an immune-mediated inflammatory response in the intestinal mucosa. Genetic susceptibility (chromosomes 12 and 16) is a factor associated with ulcerative colitis. A positive family history (observed in 1 of 6 relatives) is associated with a higher risk for developing the disease. Smoking is not associated with ulcerative colitis This relationship is reversed in Crohn disease. Environmental factors. Dietary factors: Milk consumption may exacerbate the disease. Appendectomies have a negative association with ulcerative colitis.
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