This image and the video clips shows the typical serpinginous ulcers of ulcerative colitis after using indigo carmine stain. Chromoendoscopy is characterized by intravital staining of colonic epithelium to enhance dysplastic mucosal changes, thereby allowing targeted biopsies of suspicious lesions. Indigo carmine is a contrast dye that has the ability to coat the colonic mucosa and allow identification of the disruption of normal surface mucosal grooves. In comparison, methylene blue is an absorptive dye, which avidly stains normal mucosa, but is poorly absorbed by inflamed or dysplastic mucosa. The combination of chromoendoscopy and use of magnifying colonoscopes facilitates a thorough evaluation of mucosal details, which may not be discerned on routine colonoscopy.
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