Fundic (oxyntic) gland gastritis (type A) can be associated with diffuse severe mucosal atrophy and pernicious anemia. Diffuse severe atrophic fundic gland gastritis primarily affects elderly patients, who develop achlorhydria, but with a residual ability to absorb vitamin B12. Patients with pernicious anemia generally have antibodies against parietal cells (90%) and intrinsic factor (60%) Antiparietal cell antibodies also occur in 50% of patients with gastric atrophy without pernicious anemia (but without anti-intrinsic factor antibodies) and in 10 to 15 % of normal persons.
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