Final status, after the Argon plasma coagulation therapy. Another area of intense research in the setting of BE is the study of biomarkers that may predict an increased risk of progression to cancer. 17p (p53) LOH (loss of heterozygosity) predicts progression of BE to cancer. Fluorescence in situ hybridization (FISH) is able to detect simple deletion of DNA, but in a subset of patients with BE, 17p (p53) LOH may arise by mitotic recombination or other mechanisms that cannot be detected by FISH. LOH analysis is more complex and labor-intensive, whereas FISH technology is more readily available and can be performed by various clinical laboratories.
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