Esophagectomy has been the treatment of choice for patients with Barrett's esophagus and high-grade dysplasia (HGD) or adenocarcinoma. However, the reported morbidity and mortality rates for this indication are in the range of 18% to 48% and 3% to 5%, respectively. In view of these risks, a considerable proportion of patients are unable or unwilling to undergo surgery because of comorbidity or age. A recent large prospective trial showed that HGD in Barrett's esophagus follows a relatively benign course in the majority of patients.
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