One of form of gastric adenocarcinoma is linitis plastica, composed of glandular proliferation of signet-like cells of the stomach and gastric connective tissue hiperplasia. Negatives biopsy and endoscopic examination makes the right diagnosis difficult (musosa is usually free of lession). In 75% of patients a endoscopic ultrasound may show the diagnosis, but sometimes thickness biopsy of wall is necessary. Unfortunately, the prognosis is unpleasant for the most patients.
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