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Intestinal Metaplasia (4 of 5)
Case description
There is no concerted view on regression following
eradication of H pylori. A randomised one year follow up
study reported that H pylori eradication was beneficial in
preventing progression of atrophy and IM of the gastric
mucosa and recent presentation of the results of this study
at five years has reinforced these findings, although other
studies are less conclusive. In a 2–4 year prospective study
there was no significant change in antral IM during four
years of follow up although antral atrophy declined
significantly in the period from 1 to 3 years of follow up.
However, a recent report from Japan demonstrated that
there are more studies showing regression following
eradication therapy than progression. Long term studies
are necessary to answer this question and a recent review
of the literature shows these are lacking.
eradication of H pylori. A randomised one year follow up
study reported that H pylori eradication was beneficial in
preventing progression of atrophy and IM of the gastric
mucosa and recent presentation of the results of this study
at five years has reinforced these findings, although other
studies are less conclusive. In a 2–4 year prospective study
there was no significant change in antral IM during four
years of follow up although antral atrophy declined
significantly in the period from 1 to 3 years of follow up.
However, a recent report from Japan demonstrated that
there are more studies showing regression following
eradication therapy than progression. Long term studies
are necessary to answer this question and a recent review
of the literature shows these are lacking.
