4 days after the first colonoscopy, a follow up colonoscopy was performed because the pathologist required more biopsies, the patient was under antibiotherapy. Numerous medications may produce colonic ischemia by a similar mechanism. The most common offenders are antihypertensive agents, diuretics, nonsteroidal anti -inflammatory drugs, digoxin, oral contraceptives, pseudoephedrine, cocaine, Tegaserod and alosetron. Strenuous physical activities, such as long distance running or bicycling, have been reported to lead to colonic ischemia, presumably by physiologic shunting caused by mesenteric vasoconstriction and intravascular volume depletion from dehydration.
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