Clostridium difficile colitis complicated by leukemoid reactions Patients with C difficile colitis and a leukocyte count greater than 35 x 10(9)/L have a poor prognosis with a much higher mortality rate than patients who have C difficile colitis without a leukemoid reaction. Development of pseudomembranes in the gastrointestinal tract during acute inflammatory or vascular diseases has been confined to the small and/or large bowel, with rare occurrences in the esophagus. Pseudomembranous enterocolitis is a serious, often fatal disease that usually follows antimicrobial therapy and Clostridium difficile infection. Other reported risk factors include cancer, ischemic colitis, leukemia, severe infection, and neonatal necrotizing enterocolitis.
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