Clostridium difficile-associated pseudomembranous colitis is an increasingly common nosocomial infection that usually responds to oral antibiotics. Two antibacterials have been shown to be effective in the treatment of pseudomembranous colitis: oral or parenteral metronidazole (250mg 4 times daily for 7 to 10 days) and oral vancomycin (from 125mg 3 times daily to 500mg 4 times daily in severe cases) Vancomycin is well tolerated compared with metronidazole but its cost is higher
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