Endoscopic Image of Pseudomembranous Colitis Colonoscopy in skilled hands is safe,the risk of perforation is not very great in the early stages of Pseudomembranous colitis with less severe mucosal changes. Any antibiotic can increase the risk of C difficile disease, including metronidazole and vancomycin, which are used in the treatment of CDAD. Disease has been reported following as little as one dose of antibiotic. Although the attributable relative risk has varied among studies. Fluoroquinolones, macrolides, clindamycin, beta-lactam/beta-lactamase inhibitors, and all 3 generations of cephalosporins have consistently been shown to pose a significant risk for the development of CDAD. Clostridium difficile colitis also may follow the use of certain cancer chemotherapy drugs.Pseudomembranous colitis has been reported as causing bloody diarrhea after chemotherapy.
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