Toxic megacolon is often seen in the setting of ulcerative colitis. If severe enough, many other colitides can also precipitate a toxic megacolon. Crohn disease, antibiotic-induced pseudomembranous colitis, amebiasis, Salmonella enteritis and Campylobacter enteritis infection (particularly when antimotility agents are used), and ischemic colitis are all known causes of toxic megacolon.
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