There are islands of intestinal metaplasia around the tumor as well as in the gastric body. Gastric cancers may take place in advance ages and originatemg from pre-cancerous states such as severe atrophic gastritis and colonic type of intestinal metaplasia. Especially alcian blue plus high iron diamine positive sulphomucin contents of metaplastic epithelia is suggestive for cancer development and it may be proven by histochemical studies. It has been suggested that the subtyping of intestinal metaplasia in the stomach is useful in stratifying patients with regard to risk of developing gastric cancer.
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