Chromoendoscopy using methylene blue. It is believed that adenocarcinoma develops only in epithelium containing specialized intestinal metaplasia. Therefore, investigators have focused on the utility of chromoendoscopy in identifying these areas of intestinal metaplasia for biopsy. Within this setting, showed that methylene blue, selectively stained specialized intestinal metaplasia in Barrett's esophagus, with excellent specificity and sensitivity.
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