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Macronodular Cirrhosi (2 of 2)
Case description
Classification of Cirrhosis
Morphologic: Macronodular Micronodular Mixed
Histologic: Portal, Post-necrotic, Post Hepatitic, Biliary, Congestive
ETIOLOGIC AGENTS: Genetic, Toxic, Infectious, Biliary, Vascular, Cryptogenic
This peculiar transformation of the liver was identified by
the first anatomic pathologist, Gianbattista Morgagni in his
500 autopsies published in 1761 but the name of
"cirrhosis" (greek=orange color) was given by Laennec in
1826 because of the yellowish-tan color of the cirrhotic liver
. Only in 1930, one hundred years later, however, the first
theory as to the pathogenesis of this disorder was
advanced by Roessle: parenchymal degeneration,
regeneration and scarring which is now understood
according to the following sequence:
Injury
Degeneration
Fibrosis
Formation of fibro-vascular membranes
Parenchymal dissection into nodules
Rearrangement of blood
Cirrhosis
Morphologic: Macronodular Micronodular Mixed
Histologic: Portal, Post-necrotic, Post Hepatitic, Biliary, Congestive
ETIOLOGIC AGENTS: Genetic, Toxic, Infectious, Biliary, Vascular, Cryptogenic
This peculiar transformation of the liver was identified by
the first anatomic pathologist, Gianbattista Morgagni in his
500 autopsies published in 1761 but the name of
"cirrhosis" (greek=orange color) was given by Laennec in
1826 because of the yellowish-tan color of the cirrhotic liver
. Only in 1930, one hundred years later, however, the first
theory as to the pathogenesis of this disorder was
advanced by Roessle: parenchymal degeneration,
regeneration and scarring which is now understood
according to the following sequence:
Injury
Degeneration
Fibrosis
Formation of fibro-vascular membranes
Parenchymal dissection into nodules
Rearrangement of blood
Cirrhosis
