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Gastric Cancer (12 of 15)
Case description
Histologically, gastric cancers can be separated into 2
main patterns: the intestinal (expanding) type and the
diffuse (infiltrative) type, according to the Lauren
classification system The intestinal type is characterized
by the presence of distinct glands comprising
well-differentiated columnar epithelial cells. In contrast,
the diffuse type contains poorly organized mucin-rich
(signet ring) cells. If a large proportion of the stomach is
occupied by the diffuse type lesion, the phenomenon of
linitus plastica or "leather bottle stomach" may result.
Chronic atrophic gastritis (Type B gastritis) secondary to
H pylori infection generally predisposes to the intestinal
type of gastric cancer, which is more common in high
prevalence regions such as Japan and Far East Asia. The
diffuse type, on the other hand, usually occurs in areas
with a low incidence of disease, such as the United States
main patterns: the intestinal (expanding) type and the
diffuse (infiltrative) type, according to the Lauren
classification system The intestinal type is characterized
by the presence of distinct glands comprising
well-differentiated columnar epithelial cells. In contrast,
the diffuse type contains poorly organized mucin-rich
(signet ring) cells. If a large proportion of the stomach is
occupied by the diffuse type lesion, the phenomenon of
linitus plastica or "leather bottle stomach" may result.
Chronic atrophic gastritis (Type B gastritis) secondary to
H pylori infection generally predisposes to the intestinal
type of gastric cancer, which is more common in high
prevalence regions such as Japan and Far East Asia. The
diffuse type, on the other hand, usually occurs in areas
with a low incidence of disease, such as the United States
