Polycystic kidney disease (PKD) is an inherited disease that cause an irreversible decline in kidney function. The disease is characterized by the formation of many cysts in the kidneys. There are two inherited forms: autosomal dominant PKD which occurs in adults and autosomal recessive PKD in children. Autosomal dominant PKD is caused by gene mutation in PKD1 or PKD 2. The disease is characterized by cystic expansion of the kidneys producing progressive kidney enlargement and renal insufficiency over time until one develops end stage renal failure.
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