Thrombocytopaenia (low platelets) Overview - platelet physiology, classification, pathophysiology

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Thrombocytopenia which means low platelets is associated with a variety of conditions. Thrombocytopenia is defined as a platelet count below the lower limit of normal (less than 150,000/microL). Platelets are produced in the bone marrow from megakaryocytes. Each megakoryocyte produces 1000-5000 platelets. Platelets play a key role in hemostasis forming a temporary plug. Therefore if you have low platelets you are unable to for a temporary plug and tend to bleed more easily. In order to understand platelet function, we need to revise hemostasis. Hemostasis involves three main phases vasoconstriction, platelets plug formation and coagulation

tags: thrombocytopenia Platelet disorders haematology bone marrow Complete blood count


Maciej Dobosz
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Maciej Dobosz

MD

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