Duodenal ulcer (DU) is a common condition characterized by the presence of a well-demarcated break in the mucosa that may extend into the muscularis propria of the duodenum. More than 95% of DUs are found in the first part of the duodenum; most are less than 1 cm in diameter Causes: The understanding of the etiology of DU has changed dramatically in the latter part of the 20th century. Historically, DU was thought to be a disease related to diet and environmental stress alone. Subsequent studies revealed the importance of pepsin and acid secretion in the pathogenesis of DU. The most revolutionary change in the knowledge of DU was the discovery in 1982 that the bacterium H pylori was present in most patients with DU.
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