Presence of Multiple Irregular and Large Ulcers - Suspicion of Lymphoma

Multiple irregular shallow ulcers. The paradox of lymphomas arising in the stomach has been explained by the observation of MALT in the stomach in response to infections by H pylori and by the presence of this organism in more than 90% of gastric MALT lymphomas. In some cases, low-grade MALT lymphomas have regressed with eradication of H pylori. Primary gastrointestinal non-Hodgkin lymphomas (NHLs) are a heterogeneous group of unique B- and T-cell lymphoid malignancies. Their pathology, clinical features, management, and prognosis may differ from lymphomas of lymph node origin. As an example, indolent lymphomas of lymph node origin are almost always disseminated at diagnosis, have frequent bone marrow involvement, generally respond to therapy, but continuously recur. Median survival can exceed 10 years, although cure is unusual.