Gastrointestinal Stromal Tumour of the Rectum (4 of 5)
Case description
Immunohistochemistry was positive for and CD 117 (c-kit) in the GIST.
A GIST can’t be Diagnosed by H&E
Gastrointestinal stromal tumor (GIST) is a mesenchymal
spindle cell (70-80%) or epithelioid (20-30%) neoplasm.
The diagnosis is based on a positive C-kit (CD117) stain,
which is a tyrosine kinase growth factor receptor. Some of
these tumors also respond dramatically to STI571
(Gleevec). "GIST" is relatively new terminology; these
would once have been called leiomyomas,
leiomyoblastomas, and/or leiomyosarcomas.
A GIST can’t be Diagnosed by H&E
Gastrointestinal stromal tumor (GIST) is a mesenchymal
spindle cell (70-80%) or epithelioid (20-30%) neoplasm.
The diagnosis is based on a positive C-kit (CD117) stain,
which is a tyrosine kinase growth factor receptor. Some of
these tumors also respond dramatically to STI571
(Gleevec). "GIST" is relatively new terminology; these
would once have been called leiomyomas,
leiomyoblastomas, and/or leiomyosarcomas.
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