MEDtube Science 2015 - Transplantational microchimerism – an introduction to a tolerance induction or an organ donor recipient’s epiphenomenon?

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Transplantology

Case description

Microchimerism is a presence of a small amount of cells, as well as genetic material that come from another organism. Scientists are trying to prove influence of transplantational microchimerism on different reactions that can be observed in a transplatology medicine. Conclusions are controversial and still there are no unambiguous premises regarding microchimerism. The immunological tolerance is a characteristic lack of the immunological system response to specific antigens. An achievement of full tolerance to transplanted organ can produce a possibility of discontinuation of immunosuppressive therapy and avoiding its side effects. Getting to know the real biological role of microchimerism may contribute to more effective monitoring of patients’ immunological status and immunosuppressive therapy dosage. However, it may turn out to be only an epiphenomenon connected with organ transplantation.

tags: MEDtube Science science journal 2015 microchimerism transplantology

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