Endometrial cancer (EC). It is the most common malignant neoplasm of the reproductive organs. The etiology of EC includes the stimulation of endometrial mucosa by estrogens, without opposes effect of progesterone. Human epididymis secretory protein 4 (HE4) is a marker that is widely used in the diagnosis of ovarian cancer. In recent years, studies have demonstrated HE4 overexpression in EC. The aim of our study is to compare serum HE4 marker concentration in patients with both benign pathology (BP) and EC. As well as to analyze the value of serum HE4 level, depending on clinical staging and histological grading in women with EC. A retrospective study included 202 patients diagnosed with EC and 104 patients with benign lesions within the endometrium. In each patient, the level of the HE4 marker was marked.
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