Currently, cancer constitutes a primary health problem worldwide, since elimination of cancer cells is still inadequate due to insufficient treatment strategy. The newest data has reported that PERK-dependent signaling branches have a significant impact on development and progression of many human diseases including cancer. Hypoxia is the major hallmark of tumour microenvironment, that is strictly associated with rapid cancer progression and induction of metastasis. Low oxygen tension within cancer cells may trigger aggregation of unfolded and misfolded protein within the Endoplasmic Reticulum (ER) lumen and subsequently evoke ER stress condition.
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