Approach to bleeding disorders - causes, pathophysiology and investigations

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Bleeding disorder can be either due to a problem in primary hemostasis or secondary hemostasis. Primary hemostasis related bleeding disorder are due to problems with platelets - either reduced production, increased consumption or increased destruction. Secondary hemostasis related bleeding disorders are caused by problems with the clotting factors - either a deficiency or presence of an inhibitor against the clotting factor. aPTT and PT are investigations used to see how effective the clotting factors are at forming a clot. A prolonged aPTT or PT means that the person has a tendency to bleed. 

tags: bleeding bleeding disorder Hemostasis platelets clotting aPTT PT forming a clot


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